PTFE Chemical Compatibility Checker

Last updated: April 2026

PTFE (polytetrafluoroethylene) is one of the most chemically inert materials available to engineers. Its carbon-fluorine bonds resist attack from virtually all industrial chemicals, including strong acids, bases, and organic solvents. This exceptional chemical resistance makes PTFE the material of choice for gaskets, seals, linings, and conveyor belts in corrosive environments across chemical processing, pharmaceutical, food production, and mining industries.

While PTFE resists nearly every chemical, there are a few notable exceptions. Molten alkali metals (such as sodium and potassium), elemental fluorine at elevated temperatures, and certain fluorinating agents like chlorine trifluoride can degrade PTFE. Temperature also plays a critical role — the maximum safe operating temperature varies depending on the chemical involved and its concentration.

Use the interactive checker below to verify PTFE compatibility with your specific chemical, temperature, and concentration requirements. For detailed guidance on selecting the right PTFE tape or sheet for chemical service, see our PTFE Chemical Resistance Guide.

PTFE Chemical Compatibility Chart

The table below lists the full PTFE chemical compatibility database used in our checker. Use the search box to filter by chemical name.

Why Is PTFE So Chemically Resistant?

PTFE's extraordinary chemical resistance comes from the carbon-fluorine bond, one of the strongest single bonds in organic chemistry. The fluorine atoms form a dense sheath around the carbon backbone, effectively shielding it from chemical attack. This gives PTFE a virtually inert surface that resists wetting, corrosion, and degradation from acids, bases, solvents, and oxidisers.

The only substances that can attack PTFE are those capable of breaking the C-F bond: molten alkali metals (sodium, potassium, lithium), elemental fluorine at high temperature, and certain fluorinating agents like chlorine trifluoride. In all other chemical environments, PTFE performs reliably from cryogenic temperatures up to its continuous service limit of 260°C.

How to Use This Compatibility Checker

Select the chemical you are working with from the dropdown or type to search. Enter your process operating temperature in degrees Celsius and select the approximate concentration. The tool will display the PTFE compatibility rating, maximum recommended service temperature, and any special notes or warnings for that combination.

If the checker shows a temperature warning, it means PTFE may not perform reliably under those conditions. Contact GORTEF for advice on alternative materials or modified PTFE grades that may suit your application.